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Mode of action and other features of Sildenafil

Sildenafil comes in the form of oral tablets, oral suspensions and injectable fluids. The oral tablets of Sildenafil come under the brand names Viagra and Revatio. Viagra is utilised to manage erectile dysfunction in guys, while Revatio is used to treat Pulmonary Arterial Hypertension or PAH. Sildenafil also comes in generic forms, which cost less than the branded versions. Viagra and Revatio treat specific conditions, erectile dysfunction and PAH, respectively. Generic oral tablets can treat both conditions.

How does it work?

The question is what is Sildenafil? Sildenafil features among the drugs known as Phosphodiesterase type 5 inhibitors or PDE5. The mode of action of Sildenafil depends upon the kind of conditions it treats.

Erectile dysfunction is a condition in which the man cannot get or maintain an erection long enough for sexual intercourse. This is also called impotence. Sildenafil or Viagra increases blood flow to the penis to enable the man to get and maintain an erection for sexual activity. This drug only works if the man is sexually aroused. Sildenafil does not treat sexually transmitted diseases such as syphilis, HIV, gonorrhoea, etc.

Pulmonary Arterial Hypertension (PAH) is when the blood pressure in the arteries supplying blood from the heart to the lungs increases. So, the arteries turn narrow and blocked, obstructing the blood flow, thereby increasing the blood pressure in the lungs. The heart muscles get weakened because the heart has to pump more challenging blood flowing through the arteries. Sildenafil or Revatio causes relaxation and widening of the arteries by inhibiting the activity of PDE5, which, in turn, increases the activity of cyclic guanosine monophosphate or GMP. GMP causes relaxation of the blood vessels, thereby reducing the blood pressure in the lungs.

Viagra comes as a diamond shapes blue pill, while Revatiocomes as a round white pill. Revatio also comes as a single-use vial of 10 mg capacity.

What are the features of its effects?

When it comes to erectile dysfunction, viagra or sildenafil reviews by users suggest that the effect takes about 30-60 minutes to set in. The erection can be maintained for 3-5 hours after taking the drug. Viagra’s effect persists even after ejaculation. However, if the erection persists beyond 5 hours, then it is necessary to seek medical help.

Revatiomanages the symptoms of PAH and limits the progression of this condition. It also increases the exercise capacity of the person.

Proper dosage

Sildenafil to treat erectile dysfunction, commonly known as Viagra, can be taken 4 hours to 30 minutes before sexual intercourse. For best results, it can be taken 1 hour before sexual activity. Viagra should not be taken more than once a day. In case you are suffering from other health problems and are taking certain medications, it is necessary to consult a doctor to fix the correct dosage.

The dosage of Sildenafil to treat PAH, commonly known as Revatio, is fixed by the doctor as per the patient’s medical condition. Usually, the oral tablet or suspension of Revatio is taken in doses of 5-20 mg 3 times a day. The doses are spaced 4-6 hours apart. Revatio injection is prescribed for patients who are unable to take oral medication due to any reason. The recommended dosage is usually 2.5-10 mg injected intravenously three times a day. The daily dose of Revatio should not exceed 20 mg.

Side effects

Viagra: Common side effects of Sildenafil for erectile dysfunction include headache, indigestion, fever, flushing, nosebleed, nausea, vomiting, sore throat, back pain and rashes. These side effects stop appearing as the body gets used to the drug. But in case these side effects persist and worsen over time, medical help becomes necessary.

Serious side effects include persistent erection even after 4-5 hours, hearing loss, vision loss, dizziness, chest pain, shortness of breath, fainting, and difficulty speaking. Immediate medical help is needed in such cases.

Revatio: Side effects of Sildenafil for PAH or Revatio include low blood pressure, memory problems, headache, stuffy nose, back pain, dizziness, shortness of breath and upset stomach.

Online availability

You can quickly get Sildenafil online because many pharmacies are selling this drug online. Viagra comes in boxes of 30 mg, 50 mg and 100 mg tablets. It can be obtained with or without a prescription. However, most online pharmacies offer consultations with doctors before purchasing the drug.

Revatio comes in the form of 20 mg tablets. A box can contain 30, 60 or 90 tablets. A doctor’s prescription is required to purchase Revatio from an online pharmacy.

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